ALENSLEEP

WHAT IS ALENSLEEP (MELATONIN)?

Melatonin is the natural hormone human body secretes that helps to maintain wake-sleep cycle which is also called as "biological clock". It is produced by the pineal gland in the body Melatonin is also made synthetically and available without a prescription as an over-the-counter OTC dietary supplement.
This helps you fall asleep faster and decrease the number of times you awake during the night. It also help you sleep for a longer time. Melatonin is a substance that your body normally makes.
Melatonin supplementation has been suggested to have many uses, from sleep disorders to cancer treatment. Melatonin supplement a exogeneous hormone are made synthetically

• help decrease jet lag
• adjust sleep cycles in the blind ( Non-24)
• used in insomnias

HOW DOES MELATONIN WORK?

Melatonin binds to melatonin receptor type 1A, which then acts on adenylate cylcase and the inhibition of a cAMP signal transduction pathway. Melatonin not only inhibits adenylate cyclase, but it also activates phosphilpase C. This potentiates the release of arachidonate by binding to melatonin receptors. The melatonin receptors are G protein-coupled receptors and are expressed in various tissues of the body. The binding of melatonin to MT2 receptors inhibits adenylyl cyclase which decreases the formation of cAMP. Binding to MT2 receptors probably affects PLC which increases protein kinase C 'PKC' activity. Activation of the receptor can lead to ion flux inside the cell.